Biological conversion system of bufadienolide and use thereof

一种蟾蜍甾烯的生物转化系统及其应用

Abstract

The invention provides a bufadienolide biotransformation system and its application, namely a method of using Catharanthus roseus suspension cell line to obtain new bufadienolide products by biotransformation. And the method is helpful to high efficiency synthesis of transformed products and has lower cost, and can be widely applied to large scale preparation. And the transformed products have more obvious activity of inhibiting cancel cell growth than toadpoison substrate.
本发明提供一种蟾蜍甾烯的生物转化系统及其应用,即利用长春花悬浮细胞系通过生物转化获得新的蟾蜍甾烯产物的方法。本方法有助于转化产物的高效合成,且成本较低,可广泛应用于大规模制备。转化产物具有较蟾毒底物更加明显的抑制癌细胞生长的活性。

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